What are your character's dream vacation/lifestyle changes?

Ask yourself what if time and money were no object, you had no emotional obligations and were in fine health -- what vacation or lifestyle change would you plan? Quit your job and write full time? Take a writer's retreat in some resort?

Now ask the same for your main character and obstacle/villain. If they would select the same place, you may have a new screenplay idea on your hands! Then ask what go most wrong? A natural disaster? War? a power outage? An old friend turns up?

My main character would go to Israel and relearn his Hebrew and study Kabbalah/Gematria. My Villain would become the 12th Imam and ready the world for the resurrection. My heroine would open a kosher restaurant wherever the hero settled, and would learn the Kabbalah twice as fast.